The aquaporin-4 IgG antibody appears to cause myelitis in NMOSD by binding to the water channel and activating other components of the immune system, resulting in injury to the spinal cord. The ultimate goals of these studies are to develop interventions for regeneration or remyelination of spared nerve fibers in humans and to restore function to paralyzed individuals. These techniques may aid in earlier detection of disorders such as transverse myelitis and MS. For more information on neurological disorders or research programs funded by the National Institute of Neurological Disorders and Stroke, contact the Institute's Brain Resources and Information Network (BRAIN) at:More information on transverse myelitis and spinal cord injury research supported by the NINDS and other NIH components is available through the NIH RePORTER (Information also is available from the following organizations:"Transverse Myelitis Fact Sheet", NINDS, Publication date $pubdate.NINDS health-related material is provided for information purposes only and does not necessarily represent endorsement by or an official position of the National Institute of Neurological Disorders and Stroke or any other Federal agency. LETM is not pathognomonic of NMO, therefore it is important to investigate for other causes of myelopathy in these patients. Dive into the research topics of 'Longitudinally extensive transverse myelitis'. Patients who have a clinical presentation of NMO, who have been tested with older ELISA or immunofluorescence assay and been found to be negative, should be retested with a fluorescence-activated cell sorting assay when available, particularly in the presence of recurrent LETM. Other NIH-funded researchers plan to develop MRI methodologies to non-invasively detect and characterize networks to identify the extent of injury to the spinal cord and to monitor the progression of recovery after injury. Some people recover completely and then experience a relapse. However, if there is no improvement within the first 3 to 6 months, complete recovery is unlikely (although partial recovery can still occur and still requires rehabilitation). Recent advances in the diagnosis of NMO have led to very sensitive and specific tests and advances in therapy for this disorder. SUMMARY: LETM is a heterogeneous condition. Thorough investigation of patients with LETM who are negative for NMO-IgG may lead to an alternate cause for myelopathy. Novel therapeutic strategies for LETM in the context of NMO include eculizumab, which could be considered in patients with active disease who have failed azathioprine and rituximab. Although rehabilitation cannot reverse the physical damage resulting from transverse myelitis, it can help people, even those with severe paralysis, become as functionally independent as possible and attain the best possible quality of life.Common neurological deficits resulting from transverse myelitis include severe weakness, spasticity, or paralysis; incontinence, and chronic pain. Novel therapeutic strategies for LETM in the context of NMO include eculizumab, which could be considered in patients with active disease who have failed azathioprine and rituximab.
This new approach may assess changes in lesions and otherwise normal appearing myelin, as well as address the neurological dysfunction in MS and possibly other myelin disorders such as transverse myelitis. Thorough investigation of patients with LETM who are negative for NMO-IgG may lead to an alternate cause for myelopathy. Thorough investigation of patients with LETM who are negative for NMO-IgG may lead to an alternate cause for myelopathy. Als Myelitis wird eine Entzündung des Rückenmarks oder seltener des Knochenmarks bezeichnet.. Im Folgenden wird nur die Myelitis des Rückenmarks besprochen, die Erkrankung des Knochenmarks wird unter Osteomyelitis abgehandelt.. 2 Einteilung.
Research funded by NINDS aims to develop and implement new MRI techniques to quantitatively assess the relationship between spinal cord pathology and neurological dysfunction in MS. This research may lead to a greater understanding of the mechanisms responsible for damaging myelin and may ultimately provide a means to prevent and treat transverse myelitis.Specialized cells called oligodendrocytes lay down multiple layers of myelin around axons, the long “wires” that connect brain cells.
Verwenden Sie den Chatbot, um Ihre Suche weiter zu verfeinern. 1 Definition. What is transverse myelitis?