During the process of undertaking two dedicated systematic reviews around cancer-specific QoL outcomes in men with PCa as the foundation for our guideline recommendations, the following validated PROMs were found in our searches (see Table 8.3.1).Table 8.3.1: PROMs assessing cancer specific quality of lifeFunctional Assessment of Cancer Therapy-General (FACT-G) [Physical well-being, Social/family well-being, Emotional well-being, and Functional well-being12 cancer site specific items to assess for prostate related symptoms. When a carcinoma is largely grade 4/5, identification of < 5% of Gleason grade 2 or 3 glands should not be incorporated in the GS. In this segment, you find the individual guidelines that are related to oncology. Open questions for genetic testing include the quality of tissue, which panels to use, availability of a molecular tumour board and interpretation of results. Published by Elsevier B.V. All rights reserved.
It should be emphasised that the treatment recommendations for these patients should be given after discussion in a multidisciplinary team.The PSA level that defines treatment failure depends on the primary treatment.
(See Section 6.3.4 for a more detailed discussion).Biopsy of the prostate bed and urethrovesical anastomosis of the remaining prostate after radiotherapy are only indicated if detection of a local recurrence affects treatment decisions (See Section 6.2.6.3 on imaging).Most patients who fail treatment for PCa do so within 7 years after local therapy [After radical prostatectomy rising serum PSA level is considered a BCR.After radiotherapy, an increase in PSA > 2 ng/mL above the nadir, rather than a specific threshold value, is considered as clinically meaningful BCR.Palpable nodules and increasing serum PSA are signs of local recurrence.Routinely follow up asymptomatic patients by obtaining at least a disease-specific history and serum prostate-specific antigen (PSA) measurement. The optimal local treatment is still a matter of debate [Surgery for locally advanced disease as part of a multi-modal therapy has been reported [In locally advanced disease, RCTs have clearly established that the additional use of long-term ADT combined with RT produces better OS than ADT or RT alone (see Section 6.1.3.1.4 and Tables 6.1.9 and 6.1.10). A non-inferiority randomized controlled trial.Value of urodynamics before stress urinary incontinence surgery: a randomized controlled trial.Assessment of overactive bladder symptoms: comparison of 3-day bladder diary and the overactive bladder symptoms score.Women overestimate daytime urinary frequency: the importance of the bladder diary.The association between overactive bladder symptoms and objective parameters from bladder diary and filling cystometry.EAU Guidelines on the management of non-neurogenice male LUTS.Baseline urodynamic predictors of treatment failure 1 year after mid urethral sling surgery.Normal preoperative urodynamic testing does not predict voiding dysfunction after Burch colposuspension versus pubovaginal sling.Artificial urinary sphincter for post-prostatectomy incontinence in men who had prior radiotherapy: a risk and outcome analysis.Do clinical or urodynamic parameters predict artificial urinary sphincter outcome in post-radical prostatectomy incontinence?.International Continence Society Good Urodynamic Practices and Terms 2016: urodynamics, uroflowmetry, cystometry, and pressure-flow study.A prospective multicenter randomized trial of tension-free vaginal tape and colposuspension for primary urodynamic stress incontinence: two-year follow-up.Normal lower urinary tract assessment in women: I. Uroflowmetry and post-void residual, pad tests, and bladder diaries.Pad weight testing in the evaluation of urinary incontinence.Demographic and clinical predictors of treatment failure one year after midurethral sling surgery.“The cough game”: are there characteristic urethrovesical movement patterns associated with stress incontinence?.Imaging pelvic floor disorders: trend toward comprehensive MRI.Reproducibility of dynamic MR imaging pelvic measurements: a multi-institutional study.The urethral motion profile before and after suburethral sling placement.Sonographic appearance of transobturator slings: implications for function and dysfunction.Urethral sphincter morphology and function with and without stress incontinence.Three-dimensional ultrasound of the urethral sphincter predicts continence surgery outcome.Surgical technique to overcome anatomical shortcoming: balancing post-prostatectomy continence outcomes of urethral sphincter lengths on preoperative magnetic resonance imaging.Recovery of urinary continence after radical prostatectomy: association with urethral length and urethral fibrosis measured by preoperative and postoperative endorectal magnetic resonance imaging.Risk factors for urinary incontinence among women with type 1 diabetes: findings from the epidemiology of diabetes interventions and complications study.The prevalence of lower urinary tract symptoms (LUTS) and overactive bladder (OAB) by racial/ethnic group and age: results from OAB-POLL.Medical correlates of urinary incontinence in the elderly.Risk factors for lower urinary tract symptoms in women 40 to 60 years of age.Living with urinary incontinence: a longitudinal study of older women.Systematic review of the relationship between bladder and bowel function: implications for patient management.Catheterisation Indwelling catheters in adults – Urethral and Suprapubic - Evidence-based Guidelines for Best Practice in Urological Health Care.Male external catheters in adults – Urinary catheter management - Evidence-based Guidelines for Best Practice in Urological Health Care.Are smoking and other lifestyle factors associated with female urinary incontinence?
(p = 0.02, HR: 0.80; 95% CI: 0.67-0.97) PFS: 6.3 vs. 3.2 mo.OS: 19.2 for 3 weekly vs. 17.8 mo. Saving Lives, Protecting PeopleSTD Care and Prevention Guidance During Disruption of Clinical Services Compared to a traditional catheter duration of around 1 week, some centres remove the transurethral catheter early (post-operative day 2-3), usually after thorough anastomosis with posterior reconstruction, or in patients selected peri-operatively on the basis of anastomosis quality [As an alternative to transurethral catheterisation, suprapubic catheter insertion during RP has been suggested. These synthetic analogues of LHRH, are delivered as depot injections on a 1-, 2-, 3-, 6-monthly, or yearly, basis. The guidelines include algorithms that summarise the suggested pathway for standard, Predictive factors for poor outcomes were; CRPC, distant metastases, CSS, OS, short PSA-DT, high ISUP grade, high PSA, increased age and comorbidities.